Meinhart department of mechanical and environmental engineering, ucsb. Planck and stokes equations, we examine the electrokinetic transport in a gateable. The flow control is observed at relatively low gate voltage less than 50 v, and this local flow control is primarily due to current leakage through. Use features like bookmarks, note taking and highlighting while reading electrokinetic particle transport in micronanofluidics. Field effect control of particle electrokinetic transport in micronanofluidics due to the full coupling of the fluid and particle dynamics, electrostatics, and ionic mass transport described by the model in section 2. A variety of chemical separations have been developed in microfluidic devices owing to the beneficial species transport often associated with microchip devices. Electrokinetic motion of single nanoparticles in single pdms. Observation and experimental investigation of confinement. Numerous applications of micro nanofluidics are related to particle transport in micro nanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micro nanofluidics. Web site describes electrokinetic techniques, miniaturized hplc, protein refolding, zeta potential and interface science, and other fun stuff. Enhanced throughput for electrokinetic manipulation of. Molecular simulation of electrokinetic transport in nanofluidics. A thesis presented to the graduate school of clemson university in partial fulfillment of the requirements for the degree master of science mechanical engineering by christian m.
Bhattacharyya department of mathematics indian institute of technology, kharagpur 722, india. Nanofluidic devices are often fabricated by etching tiny channels on silicon or a glass wafer and have potential applications in dna sequencing, epigenetic analysis, gene therapy, drug delivery, and toxicity analysis. Jun 24, 2011, electrokinetic particle translocation through a nanopore containing a floating electrode, electrokinetic particle transport in micro nanofluidics, 10. In this study, electrokinetic transport in a micronanofluidic system is numerically investigated by solving the transient poisson, nernstplanck, and navierstokes equations simultaneously. In this study, electrokinetic transport in a micro nanofluidic system is numerically investigated by solving the transient poisson, nernstplanck, and navierstokes equations simultaneously. Illustration of particle accumulation using the rep technique.
Electrokinetic particle translocation through a nanopore. To date, however, studies on particle electrokinetics have been limited to primarily theoretical or numerical analyses in straight microchannels of. Download it once and read it on your kindle device, pc, phones or tablets. Crossref ning hu, ye ai and shizhi qian, field effect control of electrokinetic transport in micronanofluidics, sensors and actuators b. Using numerical simulations based on coupled transient poisson. Modeling electrokinetic phenomana in micro and nanofluidics s. Ac electrokinetic pumps for micronanofluidics junqing wu, gaurav soni, dazhi wang, carl d. Microfluidics and microscale transport processes download. Field effect control of electrokinetic transport in micro.
In particular, electrokinetic effects electroosmosis and electrophoresis can dominate and voltage can be used to manipulate fluids, molecules, and particles. Jin xz, joseph s et al 2007 induced electrokinetic transport in micronanofluidic interconnect devices. Electrokinetic flow control in microfluidic chips using a. Particle tracking techniques for electrokinetic microchannel. Field effect control of electrokinetic transport in m icronanofluidics article in sensors and actuators b chemical 1611. Electrokinetic transport in micronanofluidic systems with. In general, reservoirs, channels, pumps, and valves are primary components of micro nanofluidic devices for. It is the study of the motions of ionized particles or molecules and their interactions with electric fields and the surrounding fluid. The term may be considered to be synonymous with the rather elaborate electrostrictive hydrodynamics.
Free surface problems in electrokinetic micro and nanofluidics, mechanics research. Electrokinetic transport of particles through an lshaped microchannel under dc electric fields is theoretically and experimentally investigated. These can be utilized for flow, species and particle transport control applications in micro fluidic systems. Electrokinetic motion of single nanoparticles in single. Dc electrokinetic particle transport in an lshaped. Electrokinetic transport phenomena in microfluidics.
The particle cluster is held close to the electrode surface and. Web page of microfluidics and nanofluidics laboratory at cornell university, directed by brian kirby in the mechanical and aerospace engineering department. Particleflat wall interaction odu institute of micronanotechnology 8 0 1 2 0 15 30 45 ph3. Modeling electrokinetic phenomana in micro and nanofluidics. Ionic and mass transport in micro nanofluidic devices. Optically modulated electrokinetic manipulation and. Microfluidic and nanofluidic transport cornell micro. Electrokinetic transport in micro and nano channels. An electrothermal microfluidic vortex causes rapid particle transport to the illuminated region on the electrode surface. Jan 03, 2012 the modulation of the surface potential at the channelliquid interface can also affect the electrokinetic transport of fluids and particles. Oct 26, 2010 electrokinetic transport in nanofluidics has attracted many attentions in recent years due to its potential applications in biomedical analysis and energy conversion systems. Therefore, a comprehensive understanding of electrokinetic particle transport in micro nanoscale channels is crucial to the. Field effect control of particle electrokinetic transport in m icronanofluidics due to the full coupling of the fluid and particle dynamics, electrostatics, and ionic mass transport described by the model in section 2.
Molecular simulation of electrokinetic transport in. Electrokinetic particle transport in micronanofluidics. It, however, suffers from an intrinsic drawback of low throughput due to the linear dependence of the typically very low fluid permittivity. Nanofluidics transistor 5 controllingprotein, nanoparticle or dnatranslocation 2 model description. Field effect control of electrokinetic transport in micronanofluidics article in sensors and actuators b chemical 1611.
Electrohydrodynamics ehd, also known as electrofluiddynamics efd or electrokinetics, is the study of the dynamics of electrically charged fluids. This unique characteristic allows micro nanofluidic devices as controllable platforms to precisely perform drug delivery. Electrokinetic flow diagnostics stanford university. Recent advances in direct current electrokinetic manipulation. Concentration effects, particle size to effects, and electric field channel size ratio effects on the electrokinetic motion of single nanoparticles are investigated quantitatively. Adrien plecis, antoine pallandre, annemarie haghirigosnet. It is an efficient technique for microfluidic applications with the ease of operation and integration. Institute of micronanotechnology aerospace engineering 1 high performance computing day application of comsol multiphysics in nanoscale electrokinetic transport advisor. Electrokinetic ion transport in nanofluidics and membranes. Initial, twocomponent particle tracking studies in electrokinetic flows include that of devasenathipathy et al. The book emphasizes the direct numerical simulation of.
The emphasis is placed on the direct current dc dielectrophoretic dep effect arising from the interactions between the induced spatially nonuniform electric field around the corner and the dielectric particles. Download electrokinetic particle transport in micronano. Faculty of mechanical engineering, micro and nanofluidics laboratory, technion israel institute of technology, haifa 32000, israel corresponding author. Physical chemistry chemical physics 2011, 9, 4060. Numerical analysis of electrokinetic transport in micro. There has been a growing interest in developing onlabachip micronanofluidic systems for biodetection, biotechnology, chemical and biological reactors, and medical. Electrokinetic transport in nanofluidics has attracted many attentions in recent years due to its potential applications in biomedical analysis and energy conversion systems. Electrokinetic particle transport in micro nanofluidics. The biggest challenge to model the electrokinetic transport using atomistic simulations is the extensive cost in calculation of the longrange electrostatic force between. Direct numerical simulation analysis provides a fundamental understanding of electrokinetic particle transport in micro nanofluidics involving electrophoresis, dielectrophoresis, electroosmosis, and inducedcharge electroosmosis. Crossref ning hu, ye ai and shizhi qian, field effect control of electrokinetic transport in micro nanofluidics, sensors and actuators b. Therefore, a comprehensive understanding of electrokinetic particle transport in micronanoscale channels is crucial to the development of micronanofluidic devices. Direct numerical simulation analysis provides a fundamental understanding of electrokinetic particle transport in micro.
Twovolume set comprehensively captures the crossdisciplinary breadth of the fields of micro and nanofluidics, which encompass the biological sciences, chemistry, physics. Iutam symposium on advances in micro and nanofluidics. Nanofluidics deals with the study, manipulation, and control of a few molecules or minute quantities of fluids often confined to a channel with nanoscale 1100 nm dimensions. Download pdf nanofluidics and microfluidics free online. Observation and experimental investigation of confinement effects on ion transport and electrokinetic flows at the microscale. The investigation of electrokinetic particle transport in confined microchannels has practical significances in a variety of applications ranging from traditional gel electrophoresis to electrokinetic microfluidicsbased labonachip devices. Therefore, a comprehensive understanding of electrokinetic particle transport in micro nanoscale channels is crucial to the development of micro nanofluidic devices. The modulation of the surface potential at the channelliquid interface can also affect the electrokinetic transport of fluids and particles. With applications to the biological and chemical sciences. Research assistant, department of mechanical and aerospace engineering, old dominion university, norfolk, va, usa 082009 052012 numerical study on electrokinetic fluid and particle motions in micro and nanofluidics by using comsol based on finite element with arbitrary lagrangianeulerian method to simulate. Analysis of cargo loading modes and capacity of an. Electrokinetic transport is increasingly utilized in micro nanofluidic applications due to its ability to manipulate fluids, ions, and bio particles using only electric fields without moving. Extensive theoretical analyses 412 and experimental studies 20 have been performed on the electrokinetic motion of rigid particles in micronanofluidics. Micro nanofluidics is the science of manipulating, controlling, and studying fluids at micro nanodimensions.
These can be utilized for flow, species and particle transport control applications in microfluidic systems. Numerical analysis of electrokinetic transport in micro nanofluidic interconnect preconcentrator in hydrodynamic flow. Iutam symposium on advances in micro and nanofluidics electronic resource. The system considered is a nanochannel connected with two microchannels at its ends.
Direct numerical simulation analysis provides a fundamental understanding of electrokinetic particle transport in micronanofluidics involving electrophoresis, dielectrophoresis, electroosmosis, and inducedcharge electroosmosis. Direct numerical simulation analysis surfactant science book 153 kindle edition by qian, shizhi, ai, ye. We start with an introduction into the theoretical basis of ion transport kinetics and their analogy to the charge transport in electronic systems. Electrokinetic manipulation refers to the control of particle and cell motions using an electric field. And nanofluidics electrokinetics is currently the mechanism of choice for.
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